Archived Volumes of Past Issues

Takayasu Arteritis Presenting With Severe Preeclampsia and Intrauterine Fetal Demise

Author Information

Madhva Prasad S*, Puri J**, Gupta AS***
(* Assistant Professor, ** Third Year Resident, *** Professor, Department of Obstetrics and Gynecology, Seth G.S. Medical College and K.E.M. Hospital, Mumbai, India)

Abstract

Takayasu arteritis (TKA) is a vasculitic disorder characterized by involvement of aortic arch and its branches. In pregnant patients, it is commonly associated with preeclampsia, intrauterine fetal demise (IUFD) and increased morbidity. A multigravid patient presenting with severe pre-eclampsia and IUFD, who was found to have Takayasu arteritis is reported here.

Introduction

Preeclampsia presents in myriad ways. In a patient who presents in the index pregnancy with severe preeclampsia with no prior medical evaluation, a thorough initial examination is imperative, and can lead to detection of hereto unrecognized systemic disturbances.

Case Report

A 30-year-old female married since 17 years G4P2L2A1, with eight months gestation presented to our emergency room with chief complaints of abdominal pain, giddiness and vomiting. She was unregistered, non-immunized, and was apparently asymptomatic till the day of presentation. Headache started in the occipital region and was throbbing in nature. There were no complaints of vaginal bleeding, convulsions or decreased urine output. There was no previous significant major medical or surgical history. She had two normal, uneventful home deliveries.
Patient was conscious and well oriented, with a pulse of 88 beats per minute, recorded in right radial artery and blood pressure of 170/110 mm Hg recorded in the right brachial artery. Pulses in left radial and brachial artery were not palpable, while other peripheral pulsations on left side, namely femoral, and dorsalis pedis were palpable. There were no ischemic changes over the left upper limb. History was reviewed and patient did not complain of any pain, claudication or weakness of the left upper limb. Neurological assessment did not reveal any abnormality. A physician was consulted and Doppler studies were advised. Cardiovascular and respiratory systems were unremarkable. On abdominal examination uterus was relaxed, 26 weeks size, and fetus in vertex presentation. Fetal heart sounds could not be heard on Doppler, and ultrasonography confirmed IUFD. Internal cervical os was closed and uneffaced. Premonitory symptoms were present in the form of headache, vomiting and epigastric pain, hence magnesium sulfate by Pritchard regimen was started.
A few hours later, patient developed a syncopal attack, from which she improved within a few minutes. Magnesium sulfate was discontinued and injectable phenytoin was started after physician consultation. Through the course of her stay in the hospital for around 6 days, she developed 4 episodes of syncope. History was further reviewed and patient reported having similar episodes of syncope occasionally, which had never been reported or evaluated before.
Investigations revealed mild thrombocytopenia, elevated liver enzymes (SGOT 244 and SGPT 178U/l) and otherwise normal hematological and biochemical profile. Pre-induction ripening of cervix was done with Foley catheter. Labor was augmented with oxytocin and a fresh still born female of 1024 grams was delivered. Lactation suppression was initiated.
Upper limb Doppler flows were studied which showed monophasic waveform in left ulnar, radial, brachial arteries, suggestive of occlusion. CT angiogram done post delivery confirmed long segmental complete occlusion of left subclavian and left axillary artery, with presence of calcification. However, there was no evidence of thrombosis. Cardiac echogram showed structurally normal heart without any valvular lesions or pulmonary artery hypertension. Doppler of both renal arteries did not show any evidence of renal artery stenosis.
Serum TSH was high (9.14) hence l 50 microgram of levothyroxine was started. Autoimmune markers were sent, but were negative for ANA, Anti-dsDNA, LA, aCL antibodies (IgM & IgG). Further evaluation, steroids and stenting of the subclavian artery will be planned on follow up after the puerperal period.


Figure 1. CT angiography (arrow pointing to subclavian stenosis) .

Discussion
The initial presentation of the patient was similar to classic presentation of severe preeclampsia, except that the asymmetric pulse and blood pressure recording pointed towards a peripheral arterial problem. However, the diagnosis of Takayasu arteritis could be ascertained only after the results of the imaging features was suggestive of subclavian stenosis. The occurrence of syncopal attacks also strongly supported the diagnosis. Ours being a tertiary academic center, such diagnosis could be reached with multi-disciplinary consultation.
Takayasu's arteritis is a chronic, relapsing, stenotic, inflammatory disease of medium and large-sized arteries with a propensity for the aortic arch and its branches. Incidence is around 2.5 cases per million and is more prevalent among young women and in Asians.
Hypertension is seen in up to 90% of patients with TKA.[1] However, since the patient had not received any prior antenatal care, it is postulated that hypertension was present but not detected due to lack of medical attention; her presentation was one of hypertension with superimposed preeclampsia.
Though vasculitis, i.e. histopathologic demonstration of inflamed vessels is the gold standard, it is rarely required for establishing the diagnosis, and was not done in our patient.[1] The classical CT angiographic findings include transmural calcific changes and luminal narrowing,[2] both of which were present in our patient (Figure 1). Narrowing of the arterial lumen occurs with thrombosis; however CT scan in our patient did not show the presence of any thrombus.
Pregnancies with Takayasu arteritis have been reported to have a 13-fold higher rate of obstetric complications compared to normal pregnancies. [3] Our patient presented with a blood pressure of 170/110 mmHg and intrauterine fetal demise. Pre-eclampsia, premature delivery and IUFD have been reported to be of higher incidence in patients with TKA.[4, 5, 6]
There were no cardiac events or electrocardiographic abnormalities in our patient. Cardiovascular events are a common feature in this condition. However the occurrence of the same during pregnancy has been reported to be rare,[7] as was in our case. Pulmonary hypertension is a common feature,[8] but it was ruled out in our case on cardiac echogram. The occurrence of renal artery stenosis along with concomitant subclavian stenosis detected in pregnancy has also been reported by Nalini et al.[9]
Our patient was also evaluated objectively for antiphospholipid antibody syndrome (APLA). ANA, Anti-ds DNA, aCL, LA, which were all negative. However, Anti-beta 2 glycoprotein antibody could not be done due to financial constraints. Hence, concomitant APLA syndrome cannot be ruled out. It is interesting to note that aortoarteritis has been postulated to be a precursor to APLA syndrome.[10, 11]
The treatment principles include glucocorticoids, control of hypertension, prevention of renal failure, and arterioplastic approach to stenosed vessels.[1]
To conclude, a vigilant initial general examination led to an early suspicion of a concomitant systemic cause in this patient, a rare vasculitic syndrome. Like in this case, grave medical disorders could first be recognized during pregnancy, and the opportunity should be used for thorough investigation and management. Control of blood pressure appears to be the cornerstone in the management of this disease in pregnancy. A multidisciplinary approach is needed to ensure good obstetric and neonatal outcome. This case is being presented due the novel occurrence of the rare vasculitic condition in pregnancy.

References
  1. Langford AC, Fauci AS. The Vasculitis Syndromes. In: Longo LD, Kasper DL, Jameson JL, Fauci AS, Hauser SL, Loscalzo J. Eds. Harrison’s Principles of Internal Medicine. 18th edition. McGraw Hill.
  2. Zhu FP, Luo S, Wang ZJ, Jin ZY, Zhang LJ, Lu GM. Takayasu arteritis: imaging spectrum at multidetector CT angiography. Br J Radiolog. 2012 Dec; 85(1020): e1282–92.
  3. Comarmond C, Mirault T, Biard L, Nizard J, Lambert M, Wechsler B, et al. Takayasu Arteritis and Pregnancy. Arthritis Rheumatol. 2015 Dec; 67(12): 3262–9
  4. Mandal D, Mandal S, Dattaray C, Banerjee D, Ghosh P, Ghosh A, et al. Takayasu arteritis in pregnancy: an analysis from eastern India. Arch Gynecol Obstet. 2012 Mar; 285(3): 567–71.
  5. De Jesús GR, d’Oliveira IC, dos Santos FC, Rodrigues G, Klumb EM, de Jesús NR, et al. Pregnancy may aggravate arterial hypertension in women with Takayasu arteritis. Isr Med Assoc J. 2012 Dec;14(12): 724–8
  6. Suri V, Aggarwal N, Keepanasseril A, Chopra S, Vijayvergiya R, Jain S. Pregnancy and Takayasu arteritis: a single centre experience from North India. J Obstet Gynaecol Res. 2010 Jun; 36(3): 519–24.
  7. Tanaka H, Tanaka K, Kamiya C, Iwanaga N, Yoshimatsu J. Analysis of pregnancies in women with Takayasu arteritis: complication of Takayasu arteritis involving obstetric or cardiovascular events. J Obstet Gynaecol Res. 2014 Sep; 40(9): 2031–6.
  8. Wang X, Dang A, Chen B, Lv N, Liu Q. Takayasu arteritis-associated pulmonary hypertension. J Rheumatol. 2015 Mar; 42(3): 495–503.
  9. Nalini S, Santa SA. Takayasu Arteritis with Bilateral Renal Artery Stenosis and Left Subclavian Artery Stenosis in Pregnancy. J Clin Diagn Res. Sep; 9(9):QD07-8. doi: 10.7860/JCDR/2015/14371.6485. Epub
  10. Dhaon P, Das SK, Saran RK, Parihar A. Is aorto-arteritis a manifestation of primary antiphospholipid antibody syndrome? Lupus. 2011 Dec; 20(14):1554–6.
  11. Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006 Feb; 4(2): 295–306.
Citation


Madhva Prasad S, Puri J, Gupta AS. Takayasu Arteritis Presenting With Severe Preeclampsia and Intrauterine Fetal Demise.  JPGO 2015. Volume 3 No. 4. Available from: http://www.jpgo.org/2016/04/takayasu-arteritis-presenting-with.html